Customized strategies for discovering distant ncRNA homologs
نویسندگان
چکیده
منابع مشابه
Customized strategies for discovering distant ncRNA homologs.
A large fraction of non-coding RNAs is short and/or poorly conserved in sequence. Most of the longer examples, furthermore, consist of a collection of conserved structural motifs rather than a coherent globally conserved secondary structure. As a consequence, the conceptually simple problem of homology search becomes a complex and technically demanding task. Despite the best efforts of database...
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Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from revealing the proteins’ common origin. Moreover, when a large number of substitutions are additionally involved in the divergence, the homology detection becomes difficult even at the DNA level. To cope with this situation, we pro...
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ژورنال
عنوان ژورنال: Briefings in Functional Genomics and Proteomics
سال: 2009
ISSN: 1473-9550,1477-4062
DOI: 10.1093/bfgp/elp035